Buy Synthroid Online

What is Synthroid?

Synthroid (levothyroxine) is a replacement for a hormone normally produced by your thyroid gland to regulate the body's energy and metabolism. Levothyroxine is given when the thyroid does not produce enough of this hormone on its own.

Synthroid treats hypothyroidism (low thyroid hormone). Synthroid is also used to treat or prevent goiter (enlarged thyroid gland), which can be caused by hormone imbalances, radiation treatment, surgery, or cancer.

Synthroid may also be used for purposes not listed in this medication guide.

Important information about Synthroid

You may not be able to take Synthroid if you have certain medical conditions. Tell your doctor if you have an untreated or uncontrolled adrenal gland disorder, a thyroid disorder called thyrotoxicosis, or if you have any recent or current symptoms of a heart attack.

Synthroid should not be used to treat obesity or weight problems. Dangerous side effects or death can occur from the misuse of Synthroid, especially if you are taking any other weight-loss medications or appetite suppressants.

Before taking Synthroid

Synthroid should not be used to treat obesity or weight problems. Dangerous side effects or death can occur from the misuse of levothyroxine, especially if you are taking any other weight-loss medications or appetite suppressants.

Since thyroid hormone occurs naturally in the body, almost anyone can take Synthroid. However, you may not be able to take this medication if you have certain medical conditions.

To make sure Synthroid is safe for you, tell your doctor if you have:

  • a thyroid disorder called thyrotoxicosis;

  • heart disease, coronary artery disease, or a history of blood clots;

  • diabetes (insulin or oral diabetes medication doses may need to be changed when you start taking levothyroxine);

  • anemia (lack of red blood cells);

  • osteoporosis, or low bone mineral density;

  • problems with your pituitary gland;

  • any food or drug allergies;

  • an untreated or uncontrolled adrenal gland disorder; or

  • if you have recently had a heart attack, or are having any symptoms of a heart attack (chest pain or heavy feeling, pain spreading to the jaw or shoulder, nausea, sweating, general ill feeling).

Tell your doctor if you have recently received radiation therapy with iodine (such as I-131).

FDA pregnancy category A. Synthroid is not expected to harm an unborn baby. If you become pregnant while taking levothyroxine, do not stop taking the medicine without your doctor's advice. Having low thyroid hormone levels during pregnancy could harm both mother and baby. Your dose needs may be different during pregnancy.

Levothyroxine can pass into breast milk, but it is not expected to be harmful to a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Your dose needs may be different while you are nursing.

How should I take Synthroid?

Take Synthroid exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Do not share this medication with another person, even if they have the same symptoms you have.

Synthroid works best if you take it on an empty stomach, within 30 minutes before breakfast. Follow your doctor's dosing instructions and try to take the medicine at the same time each day.

It is very important to take Synthroid with a full glass (8 ounces) of water. The levothyroxine tablet can dissolve very quickly and swell in the throat, possibly causing choking or gagging.

While using Synthroid, you may need frequent medical tests.

Tell any doctor or dentist who treats you that you are using Synthroid.

Store at room temperature away from moisture and heat.

It may take several weeks before your body starts to respond to Synthroid. Keep using this medicine even if you feel well. You may need to use this medicine for the rest of your life to replace the thyroid hormone your body cannot produce.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include headache, leg cramps, tremors, feeling nervous or irritable, chest pain, shortness of breath, and fast or pounding heartbeats.

What should I avoid while taking Synthroid?

Certain medicines can make Synthroid less effective if taken at the same time. If you use any of the following drugs, avoid taking them within 4 hours before or 4 hours after you take Synthroid:

  • calcium carbonate (Caltrate, Citracal, Oystercal, and others);

  • ferrous sulfate iron supplement;

  • sucralfate;

  • sodium polystyrene sulfonate (Kayexalate, Kionex, and others);

  • antacids that contain aluminum or magnesium (such as Acid Gone, Aldroxicon, Alternagel, Di-Gel, Gaviscon, Gelusil, Genaton, Maalox, Maldroxal, Milk of Magnesia, Mintox, Mylagen, Mylanta, Pepcid Complete, Rolaids, Rulox); or

  • cholesterol-lowering drugs cholestyramine and colestipol.

Avoid the following food products, which can make your body absorb less Synthroid: infant soy formula, cotton seed meal, walnuts, and high-fiber foods.

Synthroid side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Synthroid: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • fast or irregular heart rate;

  • fever, hot flashes, sweating;

  • sleep problems (insomnia);

  • changes in your menstrual periods; or

  • vomiting, diarrhea, appetite changes, weight changes.

Common Synthroid side effects may include mild hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Synthroid?

Many other medicines can be affected by your thyroid hormone levels. Other medicine may also increase or decrease the effects of Synthroid.

Many drugs can interact with levothyroxine and not all possible interactions are listed in this medication guide.

Tell your doctor about all medications you use, start using, or stop using during your treatment with Synthroid. This includes prescription, over-the-counter, vitamin, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

For the Consumer

Applies to levothyroxine: oral capsule liquid filled, oral tablet

Along with its needed effects, levothyroxine (the active ingredient contained in Synthroid) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking levothyroxine:

Less common
  • Chest pain or discomfort
  • decreased urine output
  • difficult or labored breathing
  • difficulty with swallowing
  • dilated neck veins
  • extreme fatigue
  • fainting
  • fast, slow, irregular, pounding, or racing heartbeat or pulse
  • fever
  • heat intolerance
  • hives or welts
  • increased blood pressure
  • increased pulse
  • irregular breathing
  • irritability
  • menstrual changes
  • nausea
  • pain or discomfort in the arms, jaw, back, or neck
  • shortness of breath
  • skin itching, rash, or redness
  • sweating
  • swelling of the eyes, face, lips, throat, or tongue
  • tightness in the chest
  • tremors
  • troubled breathing
  • Blurred or double vision
  • dizziness
  • eye pain
  • lack or slowing of normal growth in children
  • limp or walk favoring one leg
  • pain in the hip or knee
  • seizures
  • severe headache

Get emergency help immediately if any of the following symptoms of overdose occur while taking levothyroxine:

Symptoms of overdose
  • Change in consciousness
  • cold, clammy skin
  • confusion
  • disorientation
  • fast or weak pulse
  • lightheadedness
  • loss of consciousness
  • sudden headache
  • sudden loss of coordination
  • sudden slurring of speech

Some side effects of levothyroxine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Abdominal or stomach cramps
  • change in appetite
  • crying
  • diarrhea
  • false or unusual sense of well-being
  • fear
  • feeling not well or unhappy
  • feeling of discomfort
  • feeling of warmth
  • feeling things are not real
  • feelings of suspicion and distrust
  • hair loss
  • headache
  • increased appetite
  • mental depression
  • muscle weakness
  • nervousness
  • quick to react or overreact emotionally
  • rapidly changing moods
  • redness of the face, neck, arms, and occasionally, upper chest
  • restlessness
  • trouble getting pregnant
  • trouble sitting still
  • unusual tiredness or weakness
  • vomiting
  • weight gain
  • weight loss

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Applies to levothyroxine: compounding powder, injectable powder for injection, intravenous powder for injection, oral capsule, oral tablet


Levothyroxine is usually well tolerated. Side effects associated with levothyroxine (the active ingredient contained in Synthroid) therapy typically resulted from therapeutic overdosage and included the signs and symptoms of hyperthyroidism. Weight loss, increased appetite, insomnia, anxiety, heat intolerance, diarrhea or increase in bowel frequency, palpitations, hypertension, tachycardia, angina, and menstrual irregularities may be reported. Given the long half-life of levothyroxine, such effects may not be present for several weeks after therapy initiation or dosage increases.


Cardiac function was evaluated in twenty patients requiring TSH suppression for either thyroid goiter or following thyroidectomy and radioactive iodine therapy for thyroid cancer and in twenty age- and sex-matched controls. TSH suppression was associated with an increased incidence of premature ventricular beats, an increased left ventricular mass index, and enhanced left ventricular systolic function. The clinical significance of these changes remains to be determined.

A 38-year-old female experienced with severe hypothyroidism experienced myxedema coma and cardiac ischemia coincident with levothyroxine (the active ingredient contained in Synthroid) therapy. After 3 months of levothyroxine therapy (initial dose: 12.5 mcg/d; maintenance dose: 125 mcg/d), all abnormal laboratory values associated with hypothyroidism returned to normal. However, three weeks after initiating treatment, the patient reported intermittent chest pains during the course of treatment, and a coronary artery angiogram revealed diffuse stenosis of all 3 branches. She underwent coronary artery bypass grafting, with subsequent improvement in coronary perfusion.

Cardiovascular side effects have included symptoms of palpitations, hypertension, tachycardia, and angina which may be exacerbated in patients with underlying cardiovascular disorders. Ischemic heart disease and significant effects on cardiac function including an increased incidence of premature ventricular beats, an increased left ventricular mass index, and enhanced left ventricular systolic function have been reported in clinical trials.


Endocrine side effects have included changes in symptom presentation for diabetes and adrenal cortical insufficiency.

Nervous system

Nervous system side effects have rarely included seizures during initiation of therapy.


Dermatologic side effects including transient dermatologic effect and hair loss have been reported during the initial months of therapy.


Musculoskeletal side effects have included an increase risk of osteoporosis. However, data from long-term studies are conflicting.

A study evaluated the effect of long-term thyroid hormone therapy on bone mineral density in 196 women (mean age, 74.4 years) compared to a control group comprised of 795 women (mean age, 72.1 years). The mean daily thyroxine dose was 1.99 mcg/kg (range, 0.3 to 6.6 mcg/kg) with a mean duration of therapy of 20.4 years (range, less than 1 to 68 years). Women taking daily doses of 1.6 mcg/kg or more had significantly lower bone mineral density levels at the ultradistal radius, midshaft radius, hip, and lumbar spine compared to controls. However, estrogen use appeared to negate the adverse effects of thyroid hormone on bone mineral density.

Higher rates of femur fractures have been found in males (p=0.008) prescribed long-term thyroid hormone therapy as compared to controls in a case-control analysis of 23,183 patients, from the United Kingdom General Practice Research Database, prescribed thyroid hormone.